Centre for Genomic Regulation - CRG


Centre for Genomic Regulation - CRG

Centre for Genomic Regulation (CRG) The CRG is an international biomedical research institute of excellence whose mission is to discover and advance knowledge for the benefit of society, public health and economic prosperity. Research areas include human genetics and genomics, gene regulation, epigenetics, stem cell and cell biology, systems biology, cancer and other genetic-based diseases.

Duration: 6 months. In individual cases and with approval of the host research center, the planned research may be split in two stays within two years after the fellowship has been awarded.
Working language: English
Academic Requirements: PhD with at least 3 years of post-doctoral professional experience 
Documents required: As in the application form

Research at the CRG is organised into four interconnected programmes:

  1. GENE REGULATION, STEM CELLS AND CANCER PROGRAMME The objectives are to combine biochemical, cellular, genomic and computational approaches to elucidate principles of genome architecture, mechanisms and networks of gene expression and epigenetic regulation and the molecular basis of cellular decisions involved in tissue homeostasis, cell reprogramming and cancer.
  2. CELL AND DEVELOPMENTAL BIOLOGY PROGRAMME The objectives are to understand the mechanisms of cell compartmentalization, division and tissue organization and their roles in determining cell-specific properties. The research lines focus on the interactions between intercellular signaling systems and the cytoskeleton and how this contributes to the spatial organization and information processing ability of cells and groups of cells. It has an emphasis on systems with strong genetics (yeast and Drosophila) or amenable to biochemistry (Xenopus and mammalian cell lines), uses multidimensional phenotypes grounded in genomics and proteomics and integrates interdisciplinary approaches like computer modeling of morphogenesis. 
  3. BIOINFORMATICS AND GENOMICS PROGRAMME The objectives are the implementation of computational approaches to understand the encoding of biological information in the sequence of genomes and its relationship to human health and carry out research on the molecular basis of human disease, from the discovery of genes involved in human disorders to the development of preventive and therapeutic strategies. 
  4. EMBL-CRG SYSTEMS BIOLOGY PROGRAMME It aims to achieve a global quantitative understanding of biological systems, developing models that capture biological complexity and have predictive value. Common to all these groups is the integration of quantitative measurements with computer modeling of the systems analyzed.
    The CRG also integrates the CNAG, the National Centre for Genomic Analysis, one of the largest in Europe, to carry out projects in DNA sequencing and analysis in areas as cancer genetics, rare disorders, host-pathogen interactions, the preservation of endangered species, evolutionary studies and improvement of species of agricultural interest (http://www.cnag.crg.eu/). 

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